Post # 27 05302020

For the past few months, I have been noticing new tumor growth on Spiritdog’s lower jaw and right rear leg, the exact same locations of the original tumors treated with radiation in May, 2019. Subsequent biopsies of both locations confirmed the recurrence (or continuance) of sarcomas. So, sorry to say, the result of treating him with both radiation and fenbendazole has been quite disappointing.

And it is what it is.

I decided to do palliative radiation at the Michigan State University Small Animal Clinic consisting of five treatments, each one a week apart, beginning with last Thursday. The goal is to provide him with more pain free time at a cost of ~ $3000. Is it worth it? Today he acts like a normal healthy middle aged dog, so, for me, the hope of keeping him that way longer makes it a yes.

After the radiation treatments, I will also look into some form of additional treatment even including chemotherapy if I can find a modality that offers minimal side effects with extended quality of life. Maybe metronomic chemotherapy using either cytoxan or Palladia, perhaps alternating it with fenben, perhaps not, or ….. something else?

How am I dealing with this turn of events? Like any human being, I bounce back and forth. I try to follow Spiritdog’s example, living in the present, saturated with appreciation, gratitude and the joy of being with him. In this present, he is acting like a perfectly healthy dog. And sometimes I manufacture stress by sliding into my fear of him dying, even mourning his death, creating stories about the future that obliterate being present, evaporating joy.

As a quick reminder about how our body responds to our stories, from Premier Health, (www.premierhealth.com. Feb 5, 2017): As your body perceives stress, your adrenal glands make and release the hormone cortisol into your bloodstream. Often called the “stress hormone,” cortisol causes an increase in your heart rate and blood pressure.

Fortunately, I can objectively watch myself generating stress because I take my blood pressure daily with my home monitor (usually twice, in the AM and PM). I plot the data on a graph so I can see both how my BP changes daily and over time.

So, how has my concerns about Spiritdog affected my blood pressure? Bounced it up to a higher average it seems.

I confounded my own data however because during this same time I also stopped taking one pill/day of Mukta Vati, a stress reducing herbal mixture. My “before” BP was averaging ~110/65 and when I stopped taking it (and began stressing about spirit fueled by the latest diagnosis), my BP has drifted up to ~125/80, some days lower, some days higher, with morning readings almost always lower than evening readings.

One’s blood pressure matters.

From the American Heart Association: The Systolic Blood Pressure Intervention Trial, known as SPRINT, studied more than 9,300 people older than age 50 who had high blood pressure and at least one other risk factor for heart disease. By using medicines to reduce systolic blood pressure to below 120, instead of below 140:

  • rates of heart attack, heart failure and stroke went down 30 percent; and
  • rates of death from those conditions dropped nearly 25 percent.

I could start taking MV again but am going to wait a couple more weeks to see if I can practice being more conscious of my stories and let go of those that do not serve my well being.

Everyone should have a home blood pressure monitor.

It is inexpensive, reliable and offers valuable data not only about the health of our body but also insight into the workings of our brain.

Post #19 12092019

About two weeks ago, discovered another lump on Spirit’s left rear leg (he had a lump/soft tissue sarcoma on his right rear leg that was treated with surgery and radiation and so far, has not noticeably recurred). A needle biopsy showed this small lump to be non-cancerous, and consisting of inflamed tissue.

My suspicion/gut feeling is this is may be another location where cancer is attempting to get started.

Also, the lump in his jaw bone persists. Not getting bigger but not getting smaller either. This could be  a) residual dead tissue remaining from the radiation treatments he had to this location in May or b) persistent cancer in the bone of the jaw.

The veterinary oncologist recommended a wait and see approach about all of it and I basically agree – with the added provision I believe in hoping for the best but planning for the worst; which is to say, continue to treat him as if he has cancer.

So I have upped the dose of fenbendazole from 145 mg/day to 222 mg/day (the amount a 150 human would take for cancer treatment) and will do another liver health check in early January, 2020 to make sure he is handling the higher dose. If the liver is showing any signs of stress, I will drop back to the lower dose. There is no “correct dose” of course – all the uses reported in both humans and animals are anecdotal. No one knows. Given that the side effects seem to be so minimal (none noticeable in Spirit to date after three months of use), a higher dose seems worth the try.

I have also added Metatrol and Immpower, both products produced by American Biosciences to Spirit’s daily meal. I give him one capsule of each per day with his food.  (By the way, Metatrol and Metatrol Pro have identical ingredients – just a packaging/labeling difference). There is some science and quite a few scientific studies that support the supposition that the former helps fight cancer by strengthening the immune system detect and destroy cancer cells and the latter helps strengthen the immune system in general. Neither product claims to cure cancer.

American Biosciences also makes an Immpower for dogs called NK-9; it is the same product only provided in 250 mg capsules whereas Immunpower is packaged in 500 mg capsules. Since Spirit weighs 90 pounds, he would get 2 capsules of NK-9 anyway, which is the Immpower dosage – and is somewhat less expensive to buy this way.

As to Spirit, he is still doing extremely well in terms of appetite, energy and attitude – acts like a 2 year old when we are out walking.

The name of this game is to buck up, stick to the program and watch for ways to improve our game.

Post # 14 07/30/2019 New Information about CBD as a Chemo Treatment

I am a paying member of Consumer Labs, www.consumerlabs.com , an on line source of information about supplements –and they just came out with a report on CBD oil and its uses that changed my thinking about when to administer it to Spirit.

Here are the major takeaways for me in this report:

  1. Most of the research into the value of using CBD oil to treat medical conditions such as cancer is done at very high doses (like 20 mg CBD per kilogram of body weight – about 800 mg/day for Spirit!)– far above my 45-50 mg/day dose I am using for Spirit. However, at these levels, one must start to be concerned about side effects, like affecting kidney function, diarrhea, vomiting, etc.
  2. To be most effective, because CBD is fat soluable, adsorption is 5-15 times higher when given with or right after a high fat meal rather than on an empty stomach! The meal should contain 500-600 calories of fat to be helpful.
  3. With a high fat meal accompanying the CBD, the half life of CBD in the body almost doubles from 24 hours to 39 hours.
  4. CBD at the levels I am giving does not materially aid in sleeping better.
  5. Preliminary science and antidotal evidence suggests CBD does have anti cancer properties and enhances the body’s immune system response to cancer.
  6. There is also early evidence it can help with seizures, pain, anxiety, inflammation and likely other ailments too. Not my focus here, so I will not go into all the data about these conditions.
  7. Half life of CBD in the body, after hitting maximum levels in 2-5 hours, is 18-32 hours and, with continued dosing, much longer than that. So daily dosing, as I am doing with Spirit, would maintain a high level of CBD essentially all the time.
  8. CBD can interact with other medications in a negative way. Too complicated to go into here but one needs to do one’s homework and consult with others before proceeding. In Spirit’s case, he is not on any other meds so clear sailing here.
  9. As to who to buy CBD from, CL offers some information that will be helpful to some I am sure. I am already satisfied I have an excellent source with Nuleaf Naturals and will stick with them.

Based on this information, I am encouraged that the dosing level and schedule is a) not going to do any harm and b) may actually do what I am hoping – that this dose may have a positive impact on cancer metastases in Spirit – no, it not nearly as high as some studies have used but it is significantly higher than the usual – and will be doing it regularly and for a long period of time so…….who knows.

I have also immediately shifted to giving him his CBD dose right after his evening meal rather than at bedtime.

I also have added two heaping tablespoons of coconut oil to his food (worth about ~400 calories of fat). Coupled with the fat content of his regular dog food (Wellness Core dry dog food + Wellness Core canned dog food to hide his daily garlic pills for fleas and ticks + cooked hamburger + boiled egg) am confident I am up in the 500-600 calorie of fat range.

Nothing left to do now but buck up, continue with the program each and every day (practice #10, bucking up).

 

Post #13 07/26/2019 Protecting Radiated Wound Areas During Healing/Chemo Period

Below are some photos of how I protect his leg while it has no fur to protect it while we are out on our walks; this protection is done in three layers:

  1. First I lay a pad of Telfa on the wound area (available at any pharmacy, it is a non stick, soft pad that is needed while the skin in the wound area is reforming after radiation; once the skin is intact and healthy, could stop doing this step although I like the gentle protective layer it provides).
  2. I then wrap a couple of layers of Gentle Wrap to further protect the wound area, and to hold the Telfa in place. This wrap sticks to itself so is easy to work with (available at CVS).
  3. Finally, I cover the wrap with a couple of two inch wide double sided (sticks to itself ) Velcro strips that act as an “armor plate” to prevent brush and brambles from harming the wound and to keep the wrap in place.

 

The photos below show the bare leg, then with the gentle wrap over the Telfa pad and finally, with the Velcro strips as protection for the wrap. At the end of this post, I show photos of the products being used here.

The materials I am using both to protect the leg wound and the Aloe product I spray on several times a day to promote healing are shown at the end of this post.

 

 

 

 

 

When the wound condition allows, this approach is infinitely better than the array of dog boots out there, which are clumsy, rarely stay on for long, and are not fully water proof anyway. Of course, a boot was needed when the wound on his leg was still open after surgery, and his activity had to be highly restricted anyway. This period was a real headache for us both. So, boots do serve a purpose.

I should say when we walk, he is always off leash because we go to places where there are rarely people or cars, places with woods, fields, rabbits, deer, and other wildlife one would expect in this part of the world. We also go out in all kinds of weather, rain or shine, cold or hot; could be a blizzard or pouring rain but he still needs to poop. So, we go.

When we are out walking, I let him lay in puddles to cool off, walk through streams, and do whatever makes him happy. I am going to remove the wrap as soon as we get home, dry him off and spray his wound areas with Aloe Vera anyway.

These walks are his time.

His time to nose around, pee 50 times, explore the world, poop of course, and simply enjoy being alive. I want him to have a life worth living so I give him as much time as I have or he seems to need. When he is done, he tells me by lying down next to the car – in the shade during the summer, in the sun during winter.

Before cancer, I walked with him and we both got exercise; now, I have to restrict his activity until his hair grows back. I have found the best way to do this is for me to hang around the car or sit in it, maybe listening to music or read a book. Then he simply meanders around on his own at a gentle pace.

Because this is the nature of GR’s, he does not go far from where I am, ranging out not more than, say, 50 yards or so. I can almost always keep him in sight and if he is out of sight too long, I whistle him back.

I have an e-collar on him with three options: send him a brief shock, a longer one if the situation calls for it, or, as is true 99% of the time, simply a high pitched noise only he can hear but is startling to him. Finally, he comes to a just a whistle extremely well too.

I might have to shock him 1-2 times/yr these days (if he decides to chase people, another dog, or a car). If he sees and wants to chase a deer (like any bird dog, he gives up within 50 yards and comes back) or some turkeys, l let him have his fun.

We understand each other.

Post #11 07042019

It was 11 years ago today that I was writing a many page letter to my wife, Dianna, after she died on February 20, 2008 at 7:04 AM.

As recounted in my book, Dianna’s Way, a memoir about our life together, I was deeply immersed in grief over her death and this letter was my way of completing my relationship with her (practice #9 in my second book, Creating a Life that Works/11 Practices, currently being edited).

It has been my experience that when someone we love dies, our grief often includes an element of feeling guilty about something in that relationship. Not surprising. Few of us express Love perfectly in every moment of every day.

However, the beauty of guilt is it invites us to create and experience forgiveness, of self, of others.

This act opens the door wide to completing our relationships.

Simply put, the steps to completing our relationships are to a) notice there is something amiss in the relationship, b) own it (take responsibility for our own feelings, words and actions), c) forgive ourselves, then, if the shoe fits (if they have harmed us) forgive them too, d) share our completeness when appropriate, e) repair any damage we have done as best we can, f) honor their choices about whether to complete with us or not, without being bound by their choices.

 

So that was then and this is now.

I guess I never thought about it this way before but I had to complete my relationship with my dog, Spirit, too. This is an amazing insight for me!

In retrospect, completing is exactly what I did when I recognized I was transmitting negative energy into his psyche and body with my fear-filled thoughts and feelings about him dying of cancer.

Just by noticing my own negative energy, forgiving myself for harboring them, letting them go and creating a positive, constructive energy, both within my heart and mind as well as expressed in action, I could achieve completion with him. Now the way was open to moving forward with a practical, constructive plan of healing.

Of course, in all of this, I will continue to honor his choices in this matter, which may mean him choosing to end his life in a few months or not. I have no say in his choices.

Repairing the damage is simply doing what Love does (practice #5).

In this situation, this means doing whatever I am able to support him in his healing process.

This began with the insight that there was a practical way forward that had some possibility of success: radiation on the two tumor sites to kill the cancer cells in those locations, followed by an experimental CBD oil based chemotherapy for the next year – and, of course, all the associated support he needs in the form of wound healing, good diet, exercise and, in general providing a life he loves living.

Most of all, what Spirit, and any dog we have in our lives, most wants, most keenly requests, most appreciates, is always open and ready for, is that we be present to them in whatever moments we are willing to give (practice #1).

They, themselves, are masters at this practice, so teachers for us whenever we choose to be a willing student.

Doing what Love does also includes shifting my attitude to a positive, constructive frame (practice #7). There is a possible way we can achieve healing. No guarantees, the future is unknown, he may live a year or five. I don’t know. What I do know is, no matter how it turns out, I will have no regrets about everything I am doing now. Whatever happens, I will have done everything I could have done.

So, now we are in the phase of bucking up (practice #10), doing whatever it takes over the long haul.

We also know, given how this reality is designed, all of us are here only for a little while. We all leave this reality one day.

If I live that long, one day, I will experience Spirit dying, whether at age 8 or 15 or anywhere in between. When I held that squirming little puppy in my arms for the first time, I knew I was signing up for this experience too, that I would likely have the opportunity, painful as this always is, to practice letting go. (practice #8).

Life provides us with life, an amazing game to play.

 

So, why am I getting all this practice at care giving?

Life brings us the experience we need to expand our capacity for being and expressing. Nothing in life is an accident, not even “accidents.”

So, why me?

Why now?

I am naturally inclined to lean toward the mental, rational, side of experiencing life. I often love thinking about life rather than living it.

Care giving brings me back into life, into being present; how would I know if someone needs help if I am not paying attention? When present to what is, and what is is someone I love, who is in need, I am drawn into my own emotional nature, my emotional sensitivity, expressed as empathy, compassion.

Keeps me in touch with my heart.

All I need to do is pay attention to what it is saying, moment to moment.

So, care giving offers a perfect venue for practicing not only listening to my heart but to practice all of these practices.

Perfect.

 

 

Post # 10 06252019

A few days ago, I brought Spirit in for a checkup at the Animal Cancer and Imaging Center in Canton, MI.

Mostly, good news.

The only bad news is it could take 6-12 months for his hair to grow back in his radiated tumor locations.

And it might not grow back completely.

What?

I don’t mind the cosmetic aspect of it – who cares – but this means these areas have less protection from cuts and abrasions that could happen out walking, or anywhere for that matter. Not thrilled about this. Also means I will have to continue indefinitely with Aloe sprays, wrapping his leg for walks, and being careful about where we walk – romps through the woods would be not too smart right now.

Otherwise, good news.

The vet could not be absolutely sure but she thought the tumor on his jaw was a soft tissue sarcoma that had begun to penetrate into the bone rather than osteosarcoma (bone cancer, originating in the bone itself and which is incurable and aggressive). She based her opinion on the CT scan – so not the definitive diagnosis one would get from an actual biopsy. As the reader may remember from earlier posts, a needle biopsy did verify a sarcoma but could not distinguish between a soft tissue sarcoma and osteosarcoma. No certainty here but, still, I choose to be optimistic.

And, no more plastic cone around his neck!!!! (By the way, early on, I modified a store bought cone with too many mostly unworkable snaps on it and had a shoemaker sew Velcro strips on it so I could take it off and put it on in a couple of seconds. Still, both Spirit and I hated that cone!)

They also said his wounds are healing nicely. No reason for concern so far.

They had no real advice about how to administer CBD – outside their area of expertise, but they did give me some nice plastic 3 ml syringes I can use to administer it.

They did not disagree with my proposed approach of giving Spirit the entire daily dose at one time.

My strategy is based on watching how nurses administered chemo drugs to Dianna (my deceased wife). Her chemo drugs were not spread out over an entire day (although one was given in a slow drip injection through a port she carried around all day because that one could damage her heart if given all at once. None of this is an issue with CBD as it has no known serious side effects other than possible drowsiness, lethargy, etc.)

So, to allow Spirit to live his normal life as much as possible, I have decided to give him his entire dose at bedtime.

My reasoning is, this approach will:

  1. a) Aid in his sleeping (one common effect of CBD is reduced anxiety and drowsiness).
  2. b) CBD + sleep could be synergistic – both have healing characteristics.
  3. c) The effects will be mostly worn off by morning and he can enjoy being his normal self all day long.

In my next post, I will detour from the practical to the spiritual, investigating why I have found so much of my life devoted to care giving cancer patients, first for my wife, now for Spirit.

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Post #9 06192019

Today, am going to talk about the results of my research into using CBD oil for cancer treatment – for my dog, Spirit.

To review, he had two soft tissue sarcomas, one on his rear leg just above his paw and the other on his lower jaw.

I began my research through www.dogsnaturally.com and articles by Blake Armstrong and took it from there, checking various CBD oil provider websites, www.holistapet.com being one that provided a guide for dosing CBD oil for serious illnesses in dogs. One might want to also check out Armstrong’s website, cannabissupplementsforpets.com .

I finally arrived at 45-50 mg/day for Spirit, a 90 pound dog. I am using the guideline suggested on the Holistapet website for “medicinal use”. Is this the perfect dose for killing cancer cells? No one knows.

As to duration, I arbitrarily decided to do this for about one year.

Why?

In humans, chemotherapy can be over any time period but usually lasts around 6 months. I decided a lot can happen in a year so pick that as a target and see how it goes.

Ultimately, I decided to order $1000 worth of full spectrum organic CO2 extracted CBD oil from www.NuLeaf . It showed up at my door two days later, six dark 50 ml bottles, each one containing 2450 mg of the oil.

After lots of comparing, I chose Nuleaf Naturals because:

  1. a) They had the widest spectrum oil (7 components versus 4 for the others I checked – and since no one knows which components might contribute to activity, right now, more components is better, as far as I am concerned). I discovered this when I compared their analysis to that from other companies.
  2. b) Their product is extracted from their own organically grown hemp in Colorado (provided pesticide and herbicide analyses when requested showing no detectable biocides – can I prove what I have in my hands has the same analysis? No. But at least they have some data – and they sent it to me. The other companies I researched either had no data, or ignored my requests for it, or maybe were not using organically grown hemp or … who knows).
  3. c) Their oil is extracted using carbon dioxide instead of hydrocarbons – more expensive process but no chance of undesirable chemical residues either. (There are other companies using this process too, and some that don’t.)
  4. d) When I called, a human being actually answered the phone, answered my questions, and did what they said they would do when I asked for this information or that data. I was never able to reach a human being at any of the other companies I called.
  5. e) They offer higher concentrations of CBD than many other companies. This was of value to me as I want to administer a relatively concentrated dose of CBD oil in a small volume. With their 2450 mg/50 ml bottle I can squirt a 1 ml dose with a plastic syringe (no needle of course) into his mouth pretty easily.

I’m not suggesting there aren’t other good companies out there – Holista Pet, King Kanine, Hemp Your Pet and surely others too – and some of them even have better websites than Nuleaf (dosing charts for example) but I did not see others with a better product or customer service.

I make zero claims about being an expert about any of this. It is the Wild West out there with little science behind any of it. Does CBD oil actually kill cancer cells? Maybe. What dosing is best? Anyone’s guess.

Still, given the lay of the land here, I am satisfied with my choice.

Tomorrow we go for a checkup at the Animal Cancer and Imaging Center in Canton, Michigan.